In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or
sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying …

Degenerative mitral regurgitation is a major threat to public health and affects at least 24
million people worldwide, with an estimated 0.88 million disability-adjusted life years and …

Aims Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of>
2% in the general adult population. Despite this high incidence, there is a limited …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

Valvular heart disease is a common cause of morbidity and mortality worldwide and has no
effective medical therapy. Severe disease is managed with valve replacement procedures …

The fibrous annulus of the mitral valve plays an important role in valvular function and
cardiac physiology, while normal variation in the size of cardiovascular anatomy may share …

BACKGROUND: The endocardium is a crucial signaling center for cardiac valve
development and maturation. Genetic analysis has identified several human endocardial …

Background Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in
the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study …

Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of
the general population. MVP with or without mitral regurgitation can be associated with an …

Background: Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects
1 in 40 in the general population. Previous genome-wide association study has identified 6 …