Strategies toward rheumatoid arthritis therapy; the old and the new

M Abbasi, MJ Mousavi, S Jamalzehi… - Journal of cellular …, 2019 - Wiley Online Library
Currently, medications used to treat rheumatoid arthritis (RA) are glucocorticoids (GCs) and
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …

[HTML][HTML] Methotrexate mechanism in treatment of rheumatoid arthritis

B Friedman, B Cronstein - Joint bone spine, 2019 - Elsevier
Methotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to
this day is often the first line medication for RA treatment. In this review, we examine multiple …

The pretreatment gut microbiome is associated with lack of response to methotrexate in new‐onset rheumatoid arthritis

A Artacho, S Isaac, R Nayak, A Flor‐Duro… - Arthritis & …, 2021 - Wiley Online Library
Objective Although oral methotrexate (MTX) remains the anchor drug for rheumatoid arthritis
(RA), up to 50% of patients do not achieve a clinically adequate outcome. In addition, there …

Difficult-to-treat rheumatoid arthritis: an area of unmet clinical need

MJH de Hair, JWG Jacobs, JLM Schoneveld… - …, 2018 - academic.oup.com
Increased effectiveness of pharmacological treatments in early RA has led many to believe
that difficult-to-treat, established RA is a condition of the past. However, there are still plenty …

Psoriasis in skin of color: insights into the epidemiology, clinical presentation, genetics, quality-of-life impact, and treatment of psoriasis in non-white racial/ethnic …

BP Kaufman, AF Alexis - American Journal of Clinical Dermatology, 2018 - Springer
Psoriasis is a chronic inflammatory skin condition affecting diverse racial/ethnic groups
throughout the world. Large population-based studies suggest that psoriasis occurs most …

Polymorphisms and pharmacogenomics for the clinical efficacy of methotrexate in patients with rheumatoid arthritis: a systematic review and meta-analysis

Q Qiu, J Huang, X Shu, H Fan, Y Zhou, C Xiao - Scientific Reports, 2017 - nature.com
Methotrexate (MTX) is widely used and considered a first-line disease modifying anti-
rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Many of the relevant …

Genetic markers in methotrexate treatments

A Giletti, P Esperon - The pharmacogenomics journal, 2018 - nature.com
Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of
different cancers and autoimmune diseases. Despite the successful results observed, the …

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis

Q Qiu, J Huang, Y Lin, X Shu, H Fan, Z Tu, Y Zhou… - Medicine, 2017 - journals.lww.com
Background: Methotrexate (MTX) is widely used and considered a first-line disease
modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA) …

A review of liquid biopsy as a tool to assess epigenetic, cfDNA and miRNA variability as methotrexate response predictors in patients with rheumatoid arthritis

DN Daraghmeh, C King, MD Wiese - Pharmacological Research, 2021 - Elsevier
Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5–1%
of adults worldwide. Achieving long term remission or low disease activity is possible …

Biomarkers to personalize the treatment of rheumatoid arthritis: focus on autoantibodies and pharmacogenetics

V Conti, G Corbi, M Costantino, E De Bellis, V Manzo… - Biomolecules, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is very complex and
heterogeneous. If not adequately treated, RA patients are likely to manifest excess of …