Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …

Aminoacyl-tRNA synthetases (aaRSs) are crucial for the correct assembly of amino acids to
cognate tRNA to maintain the fidelity of proteosynthesis. AaRSs have become a hot target in …

Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …

A series of nineteen thiazole Schiff base derivatives 2a-2s were synthesized (Scheme 1)
and elucidated by spectral analyses (IR, 1 H NMR and HRMS). The evaluation of their …

Tuberculosis (TB), an airborne infectious disease mainly caused by Mycobacterium
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …

Multidrug‐resistant tuberculosis (MDR‐TB), defined as tuberculosis (TB) resistant to at least
isoniazid and rifampicin, is a major concern of TB control worldwide. However, the diagnosis …

Aminoacyl-tRNA synthetases (aaRSs) widely exist in organisms and mediate protein
synthesis. Inhibiting these synthetases can lead to the termination of protein synthesis and …

Laboratory evolution studies, particularly with Escherichia coli, have yielded invaluable
insights into the mechanisms of antimicrobial resistance (AMR). Recent investigations have …

New drugs to treat difficult tuberculous and nontuberculous... : Current Opinion in
Pulmonary Medicine New drugs to treat difficult tuberculous and nontuberculous …

Abstract Herein, a novel Mtb LeuRS inhibitor compound 1A was synthesized and
crystallized. And compound 1A was found to be active targeting Mtb LeuRS with IC 50 …