Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

Objective Hippocampal neuron apoptosis contributes to autism, while METTL3 has been
documented to possess great potentials in neuron apoptosis. Our study probed into the role …

Recent data from the Kollins lab ('Cannabinoid exposure and altered DNA methylation in rat
and human sperm'Epigenetics 2018; 13: 1208–1221) indicated epigenetic effects of …

Several causative factors are associated with hearing loss (HL) and brain disorders.
However, there are many unidentified disease modifiers in these conditions. Our study …

Genetic interactions play critical roles in genotype-phenotype associations. We developed a
novel interaction-integrated linear mixed model (ILMM) that integrates a priori knowledge …

Common variants account for most of the estimated heritability associated with autism
spectrum disorder (autism). Although several replicable single nucleotide polymorphisms …

Folate deficiency in the critical developmental period has been repeatedly associated with
an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological …

Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an
association of DNMT1 overexpression whereas certain variants of the gene were predicted …