Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities

A Levina, DC Crans, PA Lay - Coordination Chemistry Reviews, 2017 - Elsevier
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Vanadium in diabetes: 100 years from Phase 0 to Phase I

KH Thompson, C Orvig - Journal of inorganic biochemistry, 2006 - Elsevier
A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …

[PDF][PDF] Vanadium compounds as insulin mimics

KH Thompson, JH McNeill, C Orvig - Chemical reviews, 1999 - researchgate.net
Vanadium, element number 23, atomic weight 50.94, is normally present at very low
concentrations (< 10-8 M) in virtually all cells in plants and animals. Vanadium in oxidation …

Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease

LE Scott, C Orvig - Chemical Reviews, 2009 - ACS Publications
The field of medicinal inorganic chemistry has evolved with three conceptual aims: the
introduction of metal ions to the biological system, manipulation and redistribution of metal …

Developing vanadium as an antidiabetic or anticancer drug: A clinical and historical perspective

DC Crans, L Henry, G Cardiff, BI Posner - Met. Ions Life Sci, 2019 - degruyter.com
Vanadium has been known for centuries to have beneficial effects on health and has the
potential to be used as an alternative to other diabetic and anticancer medicines. The …

Medicinal inorganic chemistry

Z Guo, PJ Sadler - Advances in inorganic chemistry, 1999 - Elsevier
Publisher Summary Biomedical inorganic chemistry “Elemental Medicine” is an important
new area of chemistry. Platinum complexes are now among the most widely used drugs for …

Coordination chemistry of vanadium in metallopharmaceutical candidate compounds

KH Thompson, C Orvig - Coordination Chemistry Reviews, 2001 - Elsevier
The discovery of vanadium's insulin-like behaviour in vitro, and later of the orally available
glucose-and lipid-lowering capability of these same compounds in vivo, has stimulated …

[图书][B] Vanadium: chemistry, biochemistry, pharmacology and practical applications

AS Tracey, GR Willsky, ES Takeuchi - 2007 - taylorfrancis.com
The first comprehensive resource on the chemistry of vanadium, Vanadium: Chemistry,
Biochemistry, Pharmacology, and Practical Applications has evolved from over a quarter …

Metal complexes in medicinal chemistry: new vistas and challenges in drug design

KH Thompson, C Orvig - Dalton transactions, 2006 - pubs.rsc.org
An overview is presented of selected metal-based pharmaceuticals, either diagnostic or
therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds …

Health benefits of vanadium and its potential as an anticancer agent

DC Crans, L Yang, A Haase, X Yang - Met. Ions Life Sci, 2018 - degruyter.com
Vanadium compounds have been known to have beneficial therapeutic properties since the
turn of the century, but it was not until 1965 when it was discovered that those effects could …