The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a
meaningful biomarker of metabolic dysfunction. This review examines the emerging …

FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen,
glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an …

HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …

Posttranscriptional gene silencing is mediated by RNA‐induced silencing complexes
(RISCs) that contain AGO proteins and single‐stranded small RNAs. The assembly of plant …