Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of
folding into complex structures, enabling them to bind to a large variety of targets. With …

Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that
has spread rapidly around the world, leading to high mortality because of multiple organ …

Tumor immunotherapies have shown promising antitumor effects, especially immune
checkpoint inhibitors (ICIs). However, only 12.46% of the patients benefit from the ICIs, the …

In order to breed new birds with strong disease resistance, it is necessary to first understand
the mechanism of avian antiviral response. Interferon regulatory factor 7 (IRF7) is not only a …

In this study, we aimed to identify molecular markers associated with type II alveolar
epithelial cell injury in acute lung injury (ALI) models using bioinformatics methods. The …

Since its emergence, SARS-CoV-2 has been continuously evolving, hampering the
effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
clinical conditions predominantly arising from uncontrolled inflammatory reactions. It has …

Abstract Manganese (Mn 2+) has been reported to activate macrophages and NK cells, and
to induce the production of type-I interferons (IFNs) by activating the cGAS-STING pathway …

Influenza virus is a global health concern that causes from mild to severe respiratory
disease. A definitive treatment against this pathogen remains elusive, despite significant …