Modeling Alzheimer's Disease in Caenorhabditis elegans

J Alvarez, P Alvarez-Illera, J Santo-Domingo… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies

Y Jiang, LT MacNeil - Molecular Neurodegeneration, 2023 - Springer
The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …

Identification of hub genes related to Alzheimer's disease and major depressive disorder

Y Cheng, M Sun, F Wang, X Geng… - American Journal of …, 2021 - journals.sagepub.com
Background Although many studies reported a close relationship between depression and
Alzheimer's disease (AD), the underlying pathophysiological mechanism remains unclear …

Black mulberry (Morus nigra) fruit extract alleviated AD-Like symptoms induced by toxic Aβ protein in transgenic Caenorhabditis elegans via insulin DAF-16 signaling …

E Wang, N Wang, Y Zou, M Fahim, Y Zhou… - Food Research …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the most severe neurodegenerative disorders. Recently,
there is no effective treatment drug for AD. Morus nigra (M. nigra) is a black mulberry and …

Activation of microbiota sensing–free fatty acid receptor 2 signaling ameliorates amyloid-β induced neurotoxicity by modulating proteolysis-senescence axis

A Razazan, P Karunakar, SP Mishra… - Frontiers in Aging …, 2021 - frontiersin.org
Multiple emerging evidence indicates that the gut microbiota contributes to the pathology of
Alzheimer's disease (AD)—a debilitating public health problem in older adults. However …

Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics

D Paul, S Chipurupalli, A Justin, K Raja… - … of Pharmacological and …, 2020 - Elsevier
Alzheimer's disease (AD) is regarded as one of the significant health burdens, as the
prevalence is raising worldwide and gradually reaching to epidemic proportions …

Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach

AE Apostolakou, XK Sula, KC Nastou, GI Nasi… - Scientific reports, 2021 - nature.com
Alzheimer disease (AD) is a neurodegenerative disorder with an–as of yet–unclear etiology
and pathogenesis. Research to unveil disease processes underlying AD often relies on the …

Mitochondrial ribosomal protein genes connected with Alzheimer's and tellurite toxicity

L Del Giudice, P Alifano, M Calcagnile, E Di Schiavi… - Mitochondrion, 2022 - Elsevier
Mitochondrial diseases are a group of genetic disorders characterized by dysfunctional
mitochondria. Within eukaryotic cells, mitochondria contain their own ribosomes, which …

Unearthing of key genes driving the pathogenesis of Alzheimer's disease via bioinformatics

X Zhao, H Yao, X Li - Frontiers in Genetics, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with unelucidated molecular
pathogenesis. Herein, we aimed to identify potential hub genes governing the pathogenesis …

Multi‐Modal Locomotion of Caenorhabditis elegans by Magnetic Reconfiguration of 3D Microtopography

JE Park, S Yoon, J Jeon, CR Kim, S Jhang… - Advanced …, 2022 - Wiley Online Library
Miniaturized untethered soft robots are recently exploited to imitate multi‐modal curvilinear
locomotion of living creatures that perceive change of surrounding environments. Herein …