Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Epidemiology of lung cancer: Diagnosis and management of lung cancer: American College of Chest Physicians evidence-based clinical practice guidelines

AJ Alberg, MV Brock, JG Ford, JM Samet, SD Spivack - Chest, 2013 - Elsevier
Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …

Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions

V Della Latta, A Cecchettini, S Del Ry… - Pharmacological …, 2015 - Elsevier
Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe
adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of …

Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

F Luppi, M Kalluri, P Faverio, M Kreuter, G Ferrara - Respiratory Research, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …

Impact of comorbidities on mortality in patients with idiopathic pulmonary fibrosis

M Kreuter, S Ehlers-Tenenbaum, K Palmowski… - PloS one, 2016 - journals.plos.org
Introduction Comorbidities significantly influence the clinical course of idiopathic pulmonary
fibrosis (IPF). However, their prognostic impact is not fully understood. We therefore aimed to …

The impact of lung cancer on survival of idiopathic pulmonary fibrosis

S Tomassetti, C Gurioli, JH Ryu, PA Decker… - Chest, 2015 - Elsevier
BACKGROUND Lung cancer (LC) is frequently associated with idiopathic pulmonary fibrosis
(IPF). Despite this well-known association, the outcome of LC in patients with IPF is unclear …

Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development

AV Samarelli, V Masciale, B Aramini, GP Coló… - International journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: a review

T Kinoshita, T Goto - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

Nintedanib plus chemotherapy for nonsmall cell lung cancer with idiopathic pulmonary fibrosis: a randomised phase 3 trial

K Otsubo, J Kishimoto, M Ando… - European …, 2022 - Eur Respiratory Soc
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease implicated as an
independent risk factor for lung cancer. However, optimal treatment for advanced lung …

Lung cancer in patients with idiopathic pulmonary fibrosis

T Karampitsakos, V Tzilas, R Tringidou… - Pulmonary …, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology.
With a gradually increasing worldwide prevalence and a mortality rate exceeding that of …