Understanding cancer's defense against topoisomerase-active drugs: A comprehensive review
NK Sharma, A Bahot, G Sekar, M Bansode, K Khunteta… - Cancers, 2024 - mdpi.com
Simple Summary Increasing number of cancer patients and significant mortality among
these patients are attributed to many factors including anticancer drug resistance. Among a …
these patients are attributed to many factors including anticancer drug resistance. Among a …
Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and …
Herein, we envisioned the design and synthesis of novel pyrazolopyrimidines (confirmed by
elemental analysis, 1 H and 13 C NMR, and mass spectra) as multitarget-directed drug …
elemental analysis, 1 H and 13 C NMR, and mass spectra) as multitarget-directed drug …
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations
Adopting the molecular overlay approach, three novel sets of thiazepinopurines with
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4 (5H)-ones as potential apoptotic inducers targeting wild …
A novel series of ethylidenehydrazineylthiazol-4 (5H)-ones were synthesized using various
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations
FG Abdulrahman, HS Abulkhair, RA Zidan… - Future Medicinal …, 2024 - Taylor & Francis
Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers
Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
[PDF][PDF] Cracking the Code: Understanding Cancer's Defense against Topoisomerase-Active Drugs: A Comprehensive Review
BK Sinha - 2023 - preprints.org
In recent years, the emergence of cancer drug resistance is one of the crucial tumor
hallmarks which is supported by the level of genetic heterogeneity and complexities at …
hallmarks which is supported by the level of genetic heterogeneity and complexities at …
Evaluation of 1, 10-phenanthroline-based hydroxamate derivative as dual histone deacetylases/ribonucleotide reductase inhibitor with antitumor activities
Background Aberrant expression of histone deacetylases (HDACs) and ribonucleotide
reductase (RR) enzymes are commonly observed in various cancers. Researchers are …
reductase (RR) enzymes are commonly observed in various cancers. Researchers are …