This review focuses on the unique clinical and molecular pharmacology of etomidate.
Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the …

GABA (γ-aminobutyric acid) receptors, of which there are two types, are involved in inhibitory
synapses within the central nervous system. The GABA A receptor (GABAAR) has a central …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Critical illnesses are characterized by increased systemic cortisol availability, which is a vital
part of the stress response. Relative adrenal failure (later termed critical-illness-related …

Context: Activation of the hypothalamic-pituitary-adrenal (HPA) axis represents one of
several important responses to stressful events and critical illnesses. Despite a large volume …

Objective: To evaluate the effects of single-dose etomidate on the adrenal axis and mortality
in patients with severe sepsis and septic shock. Design: A systematic review of randomized …

We have compared the effects of dexmedetomidine and propofol on endocrine, metabolic,
inflammatory and cardiovascular responses in patients in the intensive care unit (ICU) after …

Objective: To summarize published data regarding the steps of rapid-sequence intubation
(RSI); review premedications, induction agents, neuromuscular blockers (NMB), and studies …

Complications of sedation with midazolam in the intensive ca... : Critical Care Medicine
Complications of sedation with midazolam in the intensive care unit and a comparison with …

Rationale Use of etomidate in the critically ill is controversial due to its links with an
inadequate response to corticotropin and potential for excess mortality. In a septic shock …