Heparin and its derivatives: challenges and advances in therapeutic biomolecules

N Banik, SB Yang, TB Kang, JH Lim, J Park - International journal of …, 2021 - mdpi.com
Heparin has been extensively studied as a safe medicine and biomolecule over the past few
decades. Heparin derivatives, including low-molecular-weight heparins (LMWH) and …

A review on multifaceted biomedical applications of heparin nanocomposites: Progress and prospects

MK Meher, G Naidu, A Mishra, KM Poluri - International Journal of …, 2024 - Elsevier
Advances in polymer-based nanocomposites have revolutionized biomedical applications
over the last two decades. Heparin (HP), being a highly bioactive polymer of biological …

Metastasis prevention: targeting causes and roots

AA Schegoleva, AA Khozyainova… - Clinical & Experimental …, 2022 - Springer
The spread of tumor cells from the primary focus, metastasis, is the main cause of cancer
mortality. Therefore, anticancer therapy should be focused on the prevention of metastatic …

[HTML][HTML] The preventive and therapeutic effects of acute and severe inflammatory disorders with heparin and heparinoid

Y Song, Y Wu, F Ding, S Li, Y Shen, B Yang, X Tang… - Biomolecules, 2024 - mdpi.com
Systematic inflammatory response syndrome (SIRS) and the accompanying sepsis pose a
huge threat to human health worldwide. Heparin is a part of the standard supportive care for …

Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis

C Casas-Arozamena, A Otero-Cacho, B Carnero… - Scientific Reports, 2021 - nature.com
Homing of circulating tumour cells (CTC) at distant sites represents a critical event in
metastasis dissemination. In addition to physical entrapment, probably responsible of the …

[HTML][HTML] Multifaceted Heparin: Diverse Applications beyond Anticoagulant Therapy

R Sultana, M Kamihira - Pharmaceuticals, 2024 - mdpi.com
Heparin, a naturally occurring polysaccharide, has fascinated researchers and clinicians for
nearly a century due to its versatile biological properties and has been used for various …

Non-Anticoagulant Activities of Low Molecular Weight Heparins—A Review

K Feng, K Wang, Y Zhou, H Xue, F Wang, H Jin… - Pharmaceuticals, 2023 - mdpi.com
Low molecular weight heparins (LMWHs) are derived from heparin through chemical or
enzymatic cleavage with an average molecular weight (Mw) of 2000–8000 Da. They exhibit …

Patterned growth of vascular cells on chemically heterogeneous surfaces modified with heparin-mimicking polymers

C Jiang, W Sun, Q Wu, X Liang, J Lei, S Zhang… - European Polymer …, 2024 - Elsevier
The extracellular matrix (ECM) can influence cell behavior due to its chemical composition
and surface morphology. Based on this concept, we modified different regions of a patterned …

Heparin–collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti‐inflammatory potency of mesenchymal stromal cells

SJ Cifuentes, M Domenech - Journal of Biomedical Materials …, 2024 - Wiley Online Library
Understanding mesenchymal stromal cells (MSCs) growth mechanisms in response to
surface chemistries is essential to optimize culture methods for high‐quality and robust cell …

Epidemiology, risk factors and mechanism of breast cancer and atrial fibrillation

X Guo, Z Zuo, X Wang, Y Sun, D Xu, G Liu, Y Tong… - Cardio-Oncology, 2024 - Springer
Cancer and cardiovascular diseases are leading causes of death worldwide. Among them,
breast cancer is one of the most common malignancies in women, while atrial fibrillation is …