Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …

As a result of the biological activities of natural flavonoids, several synthetic strategies
aiming to obtain analogues with improved potency and/or pharmacokinetic profile have …

Cancer is a serious problem affecting the health of all human societies. Chemotherapy
refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades …

Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors are being used and
developed to treat Alzheimer's disease (AD), a major type of dementia patients. Fifteen 4 …

The reaction of variously substituted 1, 2, 4-triazole derivatives with morpholine and
formaldehyde represents an efficient and easy-to-set synthetic entry toward heterocyclic N …

Triazole scaffolds, a series of 5-membered heterocycles, are well known for their high
efficacy, low toxicity, and superior pharmacokinetics. Alzheimer's disease (AD) is the first …

As a “silent threat,” Alzheimer's disease (AD) is quickly rising to the top of the list of costly
and troublesome diseases facing humanity. It is growing to be one of the most troublesome …

In this study, the synthesis and characterization of newly designed compounds containing
pyrazole, acridine, and benzothiazole groups with their biological activity potentials were …

Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been
considered one of the most privileged frameworks in the drug discovery process …