A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids

APG da Silva, WG Sganzerla, OD John… - Phytochemistry …, 2023 - Springer
Simple phenolic acids are considered the most common and widely studied bioactive
compounds belonging to plants' secondary metabolites. The simple phenolic acids can be …

Recent advances in anti-inflammation via AMPK activation

Y Xu, L Bai, X Yang, J Huang, J Wang, X Wu, J Shi - Heliyon, 2024 - cell.com
Inflammation is a complex physiological phenomenon, which is the body's defensive
response, but abnormal inflammation can have adverse effects, and many diseases are …

Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet …

G Goodarzi, SS Tehrani, G Panahi… - The Journal of …, 2023 - Elsevier
Metformin (MET) has been demonstrated to have favorable impact on nonalcoholic fatty liver
disease (NAFLD); however, the combined effect of this drug with p-coumaric acid (PCA) on …

Genistein accelerates glucose catabolism via activation the GPER-mediated cAMP/PKA-AMPK signaling pathway in broiler chickens

Q Li, Y Yang, H Wang, Z Jiang, H Ma - Life sciences, 2022 - Elsevier
Genistein, the most abundance of phytoestrogens in soybeans, has beneficial effects in
regulating metabolism-related disease; however, there is few available literatures about …

[HTML][HTML] Attenuation of hepatic fibrosis by p-Coumaric acid via modulation of NLRP3 inflammasome activation in C57BL/6 mice

TMT Truong, SH Seo, S Chung, I Kang - The Journal of Nutritional …, 2023 - Elsevier
A prolonged high-fat and high-sucrose (HFHS) diet induces hepatic inflammation and
mediates hepatic stellate cell (HSC) activation, which result in hepatic fibrosis. Aberrant …

Damp-heat constitution influences gut microbiota and urine metabolism of Chinese infants

H Zhao, Y Zong, W Li, Y Wang, W Zhao, X Meng… - Heliyon, 2023 - cell.com
Background As an increasingly popular complementary and alternative approach for early
detection and treatment of disease, traditional Chinese medicine constitution (TCMC) …

Whole grains-derived functional ingredients against hyperglycemia: Targeting hepatic glucose metabolism

Y Wang, M Fan, H Qian, H Ying, Y Li… - Critical Reviews in Food …, 2024 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is characterized by the dysregulation of glucose
homeostasis, resulting in hyperglycemia. However, concerns have been raised about the …

Ephedra alata subsp. alenda (Ephedraceae) leaf extracts: phytochemical screening, anti-diabetic, anti-obesity and anti-toxic activities on diabetic-induced liver-kidney …

SA Saidi, TM Al-Shaikh, OA Alghamdi, K Hamden - Heliyon, 2022 - pmc.ncbi.nlm.nih.gov
The study evaluated the phytochemical composition of Ephedra alata and its effects on α-
amylase and lipase enzymes and diabetic-induced liver-kidney-testes toxicities to determine …

Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

Z Yuan, X Lu, F Lei, H Sun, J Jiang, D Xing, L Du - Molecules, 2023 - mdpi.com
p-coumaric acid (p-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-
lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic …

Leptin pathway is a crucial target for anthocyanins to protect against metabolic syndrome

M Liu, S Li, M Guan, S Bai, W Bai… - Critical Reviews in Food …, 2024 - Taylor & Francis
The high prevalence of metabolic syndrome is threatening the health of populations all over
the world. Contemporary work demonstrates that high leptin concentration is directly related …