[HTML][HTML] Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M Xiao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
Necroptosis and tumor progression
Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …
[HTML][HTML] Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy
The integration of mass spectrometry-based proteomics with next-generation DNA and RNA
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …
[HTML][HTML] Targeting ferroptosis in breast cancer
Z Li, L Chen, C Chen, Y Zhou, D Hu, J Yang, Y Chen… - Biomarker …, 2020 - Springer
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …
[HTML][HTML] Ferroptosis in viral infection: the unexplored possibility
M Wang, B Joshua, N Jin, S Du, C Li - Acta Pharmacologica Sinica, 2022 - nature.com
Virus-induced cell death has long been thought of as a double-edged sword in the inhibition
or exacerbation of viral infections. The vital role of iron, an essential element for various …
or exacerbation of viral infections. The vital role of iron, an essential element for various …
The Hippo pathway effector YAP promotes ferroptosis via the E3 ligase SKP2
Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …
DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway
Recurrent breast cancer presents significant challenges with aggressive phenotypes and
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …
RIPK3 signaling and its role in the pathogenesis of cancers
S Liu, K Joshi, MF Denning, J Zhang - Cellular and Molecular Life …, 2021 - Springer
RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key
component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as …
component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as …
[HTML][HTML] Establishment of a cell necroptosis index to predict prognosis and drug sensitivity for patients with triple-negative breast cancer
J Xie, W Tian, Y Tang, Y Zou, S Zheng, L Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Necroptosis has been an alternatively identified mechanism of programmed
cancer cell death, which plays a significant role in cancer. However, research about …
cancer cell death, which plays a significant role in cancer. However, research about …
[HTML][HTML] The regulation of ferroptosis by MESH1 through the activation of the integrative stress response
All organisms exposed to metabolic and environmental stresses have developed various
stress adaptive strategies to maintain homeostasis. The main bacterial stress survival …
stress adaptive strategies to maintain homeostasis. The main bacterial stress survival …