Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis
and return-to-play/work decisions are based largely on patient reports. Numerous …

The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of
cytoplasmic components including protein aggregates, damaged organelles and invading …

The molecular substrates underlying cocaine reinforcement and addiction have been
studied for decades, with a primary focus on signaling molecules involved in modulation of …

The family of myocyte enhancer factor 2 (MEF2) transcription factors comprises four highly
conserved members that play an important role in the nervous system. They appear in …

Background Considering the potential cumulative effects of repetitive head impact (HI)
exposure, we need sensitive biomarkers to track short-and long-term effects. Circulating …

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide
adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in …

Epilepsy and Alzheimer's disease (AD) are interconnected. It is well known that seizures are
linked with cognitive impairment, and there are various shared etiologies between epilepsy …

Mounting evidence suggests that inflammation is important in epileptogenesis. Particularly
Interesting New Cysteine Histidine-rich (PINCH) protein is a highly conserved, LIM-domain …

Background Diseases and disorders with a chronic neuroinflammatory component are often
linked with changes in brain metabolism. Among neurodegenerative disorders, people living …