The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information
from the retina to the brain. Diverse insults and pathological states cause degeneration of …

A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

This brief review summarizes 60 years of conceptual advances that have demonstrated a
role for active changes in neuronal connectivity as a controller of behavior and behavioral …

In cultures of dissociated rat hippocampal neurons, persistent potentiation and depression of
glutamatergic synapses were induced by correlated spiking of presynaptic and postsynaptic …

Consolidation is the progressive postacquisition stabilization of long-term memory. The term
is commonly used to refer to two types of processes: synaptic consolidation, which is …