The RAS (renin-angiotensin system) is the part of the endocrine system that plays a prime
role in the control of essential hypertension. Since the discovery of brain RAS in the …

The wide acceptance of the oxidation theory of atherogenesis has prompted attention to
antioxidant mechanisms, particularly the prevention of lipid oxidation by high-density …

AIM: To investigate the protective effects of dexmedetomidine against hepatic
ischemia/reperfusion (IR) injury and hepatic IR induced remote organ injury. METHODS …

Background and Purpose Previous studies have demonstrated that angiotensin-converting
enzyme (ACE) is involved in brain ischemic injury. In the present study, we investigated …

Oxidative damage and apoptosis are critical factors contributing to neuronal death during a
stroke. The aim of the present study was to evaluate the neuroprotective effects of …

As a result of ischaemia/reperfusion, massive generation of reactive oxygen species occurs,
followed by decreased activity of antioxidant enzymes. Extremely low frequency …

Global cerebral ischemia is a leading cause of mortality worldwide. Several biomechanisms
play a role in the pathology of cerebral ischemia reperfusion damage, such as oxidative …

Nitric oxide (NO) is an essential messenger molecule and is associated with inflammation
and oxidative stress. Although NO has important biological functions in mammals, its role in …

Doxorubicin (DOX) is used in the treatment of cancer. However, cardiotoxicity is its major
dose-limiting factor. Mechanism of DOX–cardiac toxicity is not completely elucidated. The …

Ischemic stroke is a devastating disease with a complex pathophysiology. Galangin is a
natural flavonoid isolated from the rhizome of Alpina officinarum Hance, which has been …