Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1–
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene
expression according to parental origin. It has long been established that imprinted genes …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …

Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse
biological processes and emerged as vital players controlling tumorigenesis. Several …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …