Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness

KCS Pe, R Saetung, V Yodsurang, C Chaotham… - PLoS …, 2022 - journals.plos.org
Triple-negative breast cancer (TNBC) is characterized by excessive accumulation of tumor-
infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs consist of …

Exploring the 1, 3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic

N Gambacorta, V Gasperi, T Guzzo, FS Di Leva… - European Journal of …, 2023 - Elsevier
The discovery of selective agonists of cannabinoid receptor 2 (CB 2) is strongly pursued to
successfully tuning endocannabinoid signaling for therapeutic purposes. However, the …

TAZ facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment

A Gershoni, O Hassin, NB Nataraj, S Baruch… - Molecular …, 2023 - Wiley Online Library
The core Hippo pathway module consists of a tumour‐suppressive kinase cascade that
inhibits the transcriptional coactivators Yes‐associated protein (YAP) and WW domain …

[HTML][HTML] Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin

K Tóth, N Fekete, VK Simon, B Tóth, ÁF Kovács… - Journal of Molecular …, 2023 - Elsevier
Electrospinning is widely applied to prepare nanofibers that provide high specific surfaces,
enhanced bioavailability of poorly water-soluble drugs, moreover, enable several …

Cancer cells promote immune regulatory function of macrophages by upregulating scavenger receptor MARCO expression

C Gu, M Wiest, W Zhang, K Halder… - The Journal of …, 2023 - journals.aai.org
Expression of macrophage receptor with collagenous structure (MARCO) by tumor-
associated macrophages is associated with poor prognosis of multiple types of cancer. In …

The ability of supercritical CO 2 carrot and pumpkin extracts to counteract inflammation and oxidative stress in RAW 264.7 macrophages stimulated with LPS or MDA …

L Frattaruolo, M Durante, MS Cappello… - Food & Function, 2023 - pubs.rsc.org
Supercritical fluid extraction with CO2 (SFE) is an alternative technology to conventional
solvent extraction (CSE), to obtain food-grade bioactives from plants. Here, SFE and CSE …

The Omega-3 docosahexaenoyl ethanolamide reduces CCL5 secretion in triple negative breast cancer cells affecting tumor progression and macrophage recruitment

G Augimeri, M Fiorillo, C Morelli, S Panza, C Giordano… - Cancers, 2023 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) is associated with a generally poor
breast cancer outcome, intensifying the need for novel therapeutic strategies beyond …

Immunomodulatory potential of Clinacanthus nutans extracts in the co-culture of triple-negative breast cancer cells, MDA-MB-231, and THP-1 macrophages

FJ Nordin, L Pearanpan, KM Chan, E Kumolosasi… - Plos one, 2021 - journals.plos.org
Triple-negative breast cancer is the main type of breast carcinoma that causes mortality
among women because of the limited treatment options and high recurrence. Chronic …

Dynamic changes in maternal immune biomarkers during labor in nulliparous vs multiparous women

W Ding, SL Lau, CC Wang, T Zhang, O Getsko… - American Journal of …, 2022 - Elsevier
Background Immunomodulation is observed in human parturition. However, data from
longitudinal studies for the prelabor phase and the active phase of labor are lacking, and no …

FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro

SR Van Eyssen, A Samarkina, O Isbilen, MS Zeden… - Pathogens, 2023 - mdpi.com
Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known
as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established …