Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Fundamental biological processes are carried out by curved epithelial sheets that enclose a
pressurized lumen. How these sheets develop and withstand three-dimensional …

This review summarizes theoretical progress in the field of active matter, placing it in the
context of recent experiments. This approach offers a unified framework for the mechanical …

Growing evidence suggests that the physical properties of the cellular microenvironment
influence cell migration. However, it is not currently understood how active physical …

One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

Abstract Development, regeneration and cancer involve drastic transitions in tissue
morphology. In analogy with the behaviour of inert fluids, some of these transitions have …

Regulating the emergence of leaders is a central aspect of collective cell migration, but the
underlying mechanisms remain ambiguous. Here we show that the selective emergence of …

Adherent cells, crawling slugs, peeling paint, sessile liquid drops, bearings and many other
living and non-living systems apply forces to solid substrates. Traction force microscopy …