[HTML][HTML] Human trials exploring anti-aging medicines

L Guarente, DA Sinclair, G Kroemer - Cell Metabolism, 2024 - cell.com
Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Gut microbiome-targeted therapies for Alzheimer's disease

T Zhang, G Gao, LY Kwok, Z Sun - Gut microbes, 2023 - Taylor & Francis
The advent of highthroughput 'omics' technologies has improved our knowledge of gut
microbiome in human health and disease, including Alzheimer's disease (AD), a …

[HTML][HTML] Microbiota-gut-brain Axis Dysregulation in Alzheimer's disease: Multi-pathway effects and therapeutic potential

L Qu, Y Li, F Liu, Y Fang, J He, J Ma, T Xu… - Aging and …, 2024 - ncbi.nlm.nih.gov
An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the
gut microbiota. Alterations in intestinal permeability brought on by gut microbiota …

The gut microbiota–brain axis in neurological disorders

M You, N Chen, Y Yang, L Cheng, H He, Y Cai… - MedComm, 2024 - Wiley Online Library
Previous studies have shown a bidirectional communication between human gut microbiota
and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the …

[HTML][HTML] Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with …

D Nimmons, N Aker, A Burnand, KP Jordan… - Neuroscience & …, 2024 - Elsevier
People living with dementia commonly experience anxiety, which is often challenging to
manage. We investigated the effectiveness of treatments for the management of anxiety in …

Gut microbiome and Alzheimer's disease: What we know and what remains to be explored

B Kapoor, P Biswas, M Gulati, P Rani, R Gupta - Ageing Research Reviews, 2024 - Elsevier
With advancement in human microbiome research, an increasing number of scientific
evidences have endorsed the key role of gut microbiota in the pathogenesis of Alzheimer …

Quality management of probiotics: Ensuring safety and maximizing health benefits

JJ Ahire, A Rohilla, V Kumar, A Tiwari - Current microbiology, 2024 - Springer
Consumption of probiotics, which are beneficial live microorganisms, has received a lot of
attention because of their potential to improve health and wellness. Robust quality control …

[HTML][HTML] Thinking outside the brain: gut microbiome influence on innate immunity within neurodegenerative disease

AR Merchak, MKL Bolen, MG Tansey, KB Menees - Neurotherapeutics, 2024 - Elsevier
The complex network of factors that contribute to neurodegeneration have hampered the
discovery of effective preventative measures. While much work has focused on brain-first …