Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Cortical malformations: lessons in human brain development
L Subramanian, ME Calcagnotto… - Frontiers in cellular …, 2020 - frontiersin.org
Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …
developmental steps. These steps have evolved across species with the emergence of …
The fraction of cortical GABAergic neurons is constant from near the start of cortical neurogenesis to adulthood
S Sahara, Y Yanagawa, DDM O'Leary… - Journal of …, 2012 - Soc Neuroscience
Approximately one in five neurons is GABAergic in many neocortical areas and species,
forming a critical balance between inhibition and excitation in adult circuits. During …
forming a critical balance between inhibition and excitation in adult circuits. During …
Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair
Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …
Integrative mechanisms of oriented neuronal migration in the developing brain
I Evsyukova, C Plestant, ES Anton - Annual review of cell and …, 2013 - annualreviews.org
The emergence of functional neuronal connectivity in the developing cerebral cortex
depends on neuronal migration. This process enables appropriate positioning of neurons …
depends on neuronal migration. This process enables appropriate positioning of neurons …
ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease
Ligands for ErbB1-4 receptor tyrosine kinases, such as epidermal growth factor (EGF) and
neuregulins, regulate brain development and function. Thus, abnormalities in their signaling …
neuregulins, regulate brain development and function. Thus, abnormalities in their signaling …
Neuronal migration abnormalities and its possible implications for schizophrenia
K Muraki, K Tanigaki - Frontiers in neuroscience, 2015 - frontiersin.org
Schizophrenia is a complex mental disorder that displays behavioral deficits such as
decreased sensory gating, reduced social interaction and working memory deficits. The …
decreased sensory gating, reduced social interaction and working memory deficits. The …
Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain
Neuregulin 1 (NRG1) and its receptor ErbB4 are schizophrenia risk genes. NRG1-ErbB4
signaling plays a critical role in neural development and regulates neurotransmission and …
signaling plays a critical role in neural development and regulates neurotransmission and …
Cellular resolution anatomical and molecular atlases for prenatal human brains
SL Ding, JJ Royall, P Lesnar, BAC Facer… - Journal of …, 2022 - Wiley Online Library
Increasing interest in studies of prenatal human brain development, particularly using new
single‐cell genomics and anatomical technologies to create cell atlases, creates a strong …
single‐cell genomics and anatomical technologies to create cell atlases, creates a strong …
Neuregulin 3 mediates cortical plate invasion and laminar allocation of GABAergic interneurons
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory
interneurons. These two main classes of cortical neurons follow largely different genetic …
interneurons. These two main classes of cortical neurons follow largely different genetic …