The direct chiral separation by chiral stationary phases (CSPs) is one of the most important
techniques to analyze enantiomeric purity as well as to get enantiomerically pure material …

Temperature control in lipase-catalyzed resolutions has been recently focused attention due
to its simplicity and reliability for enhancement of the enantioselectivity. Lowering the …

It is recognized within the pharmaceutical industry that the chiral nature of biosystems results
in enantiospecific drug interactions. As a consequence, analytical methods are required to …

Synthesis of a library of pyrrolo [2, 1-c][1, 4]-benzodiazepines derived from spiro bicyclic d-or
l-proline analogues containing a d-or l-fructose moiety was developed. The l-fructose moiety …

We recently reported the enantioselective syntheses of quaternary 1, 4-benzodiazepin-2-
ones via memory of chirality. The success of this method depends on formation of …

It has now been found that compounds of the present invention as described in Formula (I)
possess certain advantages because of their structural design. The benzodiazepines …

For the enhancement of enantioselectivity and acceleration of the reaction rate in the lipase-
catalyzed resolution of primary alcohols, the use of a very low reaction temperature (− 30° C) …

It has now been found that compounds of the present invention as described in Formula (I)
possess certain advantages because of their structural design. The benzodiazepines …

Abstract Novel, conformationally constrained 1, 4‐benzodiazepine‐2, 5‐diones containing
both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric …

Benzoylformate decarboxylase (BFD) from Pseudomonas putida is a thiamine diphosphate‐
dependent (ThDP) enzyme that catalyzes the asymmetric C C bond formation to (S)‐2 …