Glycogen and its metabolism: some new developments and old themes

PJ Roach, AA Depaoli-Roach, TD Hurley… - Biochemical …, 2012 - portlandpress.com
Glycogen is a branched polymer of glucose that acts as a store of energy in times of
nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of …

Starch: its metabolism, evolution, and biotechnological modification in plants

SC Zeeman, J Kossmann… - Annual review of plant …, 2010 - annualreviews.org
Starch is the most widespread and abundant storage carbohydrate in plants. We depend
upon starch for our nutrition, exploit its unique properties in industry, and use it as a …

Protein tyrosine phosphatases–from housekeeping enzymes to master regulators of signal transduction

NK Tonks - The FEBS journal, 2013 - Wiley Online Library
There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

RC Sun, LEA Young, RC Bruntz, KH Markussen… - Cell metabolism, 2021 - cell.com
Glycosylation defects are a hallmark of many nervous system diseases. However, the
molecular and metabolic basis for this pathology is not fully understood. In this study, we …

The dynamic life of the glycogen granule

C Prats, TE Graham, J Shearer - Journal of Biological Chemistry, 2018 - ASBMB
Glycogen, the primary storage form of glucose, is a rapid and accessible form of energy that
can be supplied to tissues on demand. Each glycogen granule, or" glycosome," is …

Lafora disease—from pathogenesis to treatment strategies

F Nitschke, SJ Ahonen, S Nitschke, S Mitra… - Nature Reviews …, 2018 - nature.com
Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy. The
disease usually manifests in previously healthy adolescents, and death commonly occurs …

The evolution of glycogen and starch metabolism in eukaryotes gives molecular clues to understand the establishment of plastid endosymbiosis

S Ball, C Colleoni, U Cenci, JN Raj… - Journal of experimental …, 2011 - academic.oup.com
Solid semi-crystalline starch and hydrosoluble glycogen define two distinct physical states of
the same type of storage polysaccharide. Appearance of semi-crystalline storage …

Non-lysine ubiquitylation: Doing things differently

IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …

Lafora disease

J Turnbull, E Tiberia, P Striano, P Genton… - Epileptic …, 2016 - Wiley Online Library
Lafora disease (LD) is an autosomal recessive progressive myoclonus epilepsy due to
mutations in the EPM2A (laforin) and EPM2B (malin) genes, with no substantial genotype …

Biochemical and clinical aspects of glycogen storage diseases

SS Ellingwood, A Cheng - Journal of Endocrinology, 2018 - joe.bioscientifica.com
The synthesis of glycogen represents a key pathway for the disposal of excess glucose
while its degradation is crucial for providing energy during exercise and times of need. The …