Type 1 diabetes mellitus

A Katsarou, S Gudbjörnsdottir, A Rawshani… - Nature reviews Disease …, 2017 - nature.com
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift

KD Deane, VM Holers - Arthritis & Rheumatology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …

Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001-2017

JM Lawrence, J Divers, S Isom, S Saydah… - Jama, 2021 - jamanetwork.com
Importance Changes in the prevalence of youth-onset diabetes have previously been
observed. Objective To estimate changes in prevalence of type 1 and type 2 diabetes in …

[HTML][HTML] Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012

EJ Mayer-Davis, JM Lawrence… - … England Journal of …, 2017 - Mass Medical Soc
Background Diagnoses of type 1 and type 2 diabetes in youths present a substantial clinical
and public health burden. The prevalence of these diseases increased in the 2001–2009 …

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

T Hollstein, DM Schulte, J Schulz, A Glück… - Nature …, 2020 - nature.com
Here we report a case where the manifestations of insulin-dependent diabetes occurred
following SARS-CoV-2 infection in a young individual in the absence of autoantibodies …

Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood

D Dabelea, JM Stafford, EJ Mayer-Davis, R D'Agostino… - Jama, 2017 - jamanetwork.com
Importance The burden and determinants of complications and comorbidities in
contemporary youth-onset diabetes are unknown. Objective To determine the prevalence of …

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

M Fasolino, GW Schwartz, AR Patil, A Mongia… - Nature …, 2022 - nature.com
Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009

D Dabelea, EJ Mayer-Davis, S Saydah, G Imperatore… - Jama, 2014 - jamanetwork.com
Importance Despite concern about an “epidemic,” there are limited data on trends in
prevalence of either type 1 or type 2 diabetes across US race and ethnic groups. Objective …

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

JP Krischer, KF Lynch, DA Schatz, J Ilonen, Å Lernmark… - Diabetologia, 2015 - Springer
Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1
diabetes. These autoantibodies are detectable for a variable period of time before diabetes …

A combined risk score enhances prediction of type 1 diabetes among susceptible children

LA Ferrat, K Vehik, SA Sharp, Å Lernmark… - Nature medicine, 2020 - nature.com
Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …