Mycobacterium tuberculosis (M. tb), the causative agent of TB, is a recalcitrant pathogen that
is rife around the world, latently infecting approximately a quarter of the worldwide …

Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

This analysis of the global clinical antibacterial pipeline was done in support of the Global
Action Plan on Antimicrobial Resistance. The study analysed to what extent antibacterial …

Tuberculosis (TB) is one of the emerging infectious diseases in the world. DprE1 (
Decaprenylphosphoryl-β-d-ribose 2′-epimerase), an enzyme accountable for …

The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Small molecules with antitubercular activity containing the pyrimidine motif in their structure
have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 …

Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …

Enoyl acyl carrier protein reductase (InhA) is a key enzyme involved in fatty acid synthesis
mainly mycolic acid biosynthesis that is a part of NADH dependent acyl carrier protein …

Multiple drug discovery initiatives for tuberculosis are currently ongoing to identify and
develop new potent drugs with novel targets in order to shorten treatment duration. One of …

This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …