Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

The movement of lipids within and between intracellular membranes is mediated by different
lipid transport mechanisms and is crucial for maintaining the identities of different cellular …

The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …

Sac1 phosphoinositide (PI) phosphatases are essential regulators of PI-signaling networks.
Yeast Sac1, an integral endoplasmic reticulum (ER) membrane protein, controls PI4P levels …

Osh/Orp proteins transport sterols between organelles and are involved in phosphoinositide
metabolism. The link between these two aspects remains elusive. Using novel assays, we …

Oxysterol-binding protein (OSBP) and its related proteins (ORPs) constitute a large and
evolutionarily conserved family of lipid-binding proteins that target organelle membranes to …

Lipids are unevenly distributed within eukaryotic cells, thus defining organelle identity. How
non-vesicular transport mechanisms generate these lipid gradients between membranes …

Thymol is a natural plant-derived compound that has been widely used in pharmaceutical
and food preservation applications. However, the antifungal mechanism for thymol against …

Oxysterol-binding protein (OSBP)-related proteins (ORPs) are lipid-binding proteins that are
conserved from yeast to humans. They are implicated in many cellular processes including …

To maintain an asymmetric distribution of ions across membranes, protein pumps displace
ions against their concentration gradient by using chemical energy. Here, we describe a …