HSP70 multi-functionality in cancer

Z Albakova, GA Armeev, LM Kanevskiy, EI Kovalenko… - Cells, 2020 - mdpi.com
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Molecular chaperones in cancer stem cells: determinants of stemness and potential targets for antitumor therapy

A Kabakov, A Yakimova, O Matchuk - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …

Hsp70 in cancer: A double agent in the battle between survival and death

MA Vostakolaei, L Hatami‐Baroogh… - Journal of cellular …, 2021 - Wiley Online Library
The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …

Highly sensitive electrochemical detection of circulating EpCAM-positive tumor cells using a dual signal amplification strategy

AB Hashkavayi, BS Cha, SH Hwang, J Kim… - Sensors and Actuators B …, 2021 - Elsevier
Circulating tumor cells (CTCs) play an important role in diagnosing cancer and metastasis;
thus, appropriate sensors are required for analyzing CTCs in patient samples. Here, we …

Membrane-associated heat shock proteins in oncology: from basic research to new theranostic targets

M Shevtsov, Z Balogi, W Khachatryan, H Gao, L Vígh… - Cells, 2020 - mdpi.com
Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …

Multivalent aptamer nanoscaffold cytosensor for glioma circulating tumor cells during Epithelial–Mesenchymal transition

G Wang, Y Zhang, S Tang, S Chen, F Zou… - Biosensors and …, 2023 - Elsevier
The key factor that causes glioma invasion and metastasis is circulating tumor cells (CTCs)
undergoing epithelial–mesenchymal transition (EMT). Effective analysis of EMT-CTCs can …

Effective circulating tumor cell isolation using epithelial and mesenchymal markers in prostate and pancreatic cancer patients

J Cha, H Cho, JS Chung, JS Park, KH Han - Cancers, 2023 - mdpi.com
Simple Summary Circulating tumor cells (CTCs) are important diagnostic and prognostic
markers in cancer patients. However, current methods for isolating CTCs primarily focus on …

Enhancing the cytotoxicity of immunotoxins by facilitating their dissociation from target receptors under the reducing conditions of the endocytic pathway

HJ Lee, BH Chae, DH Ko, SG Lee, SR Yoon… - International Journal of …, 2024 - Elsevier
Immunotoxins (ITs) are recombinant chimeric proteins that combine a protein toxin with a
targeting moiety to facilitate the selective delivery of the toxin to cancer cells. Here, we …

Chaperone duality: the role of extracellular and intracellular HSP70 as a biomarker of endothelial dysfunction in the development of atherosclerosis

LC Costa-Beber, GE Hirsch, TG Heck… - Archives of Physiology …, 2022 - Taylor & Francis
The 70-kDa heat shock proteins (HSP70) may provide relevant information about the
endothelial dysfunction in cardiovascular diseases. Located in the intracellular milieu …

Hsp70—A universal biomarker for predicting therapeutic failure in human female cancers and a target for CTC isolation in advanced cancers

A Xanthopoulos, AK Samt, C Guder, N Taylor… - Biomedicines, 2023 - mdpi.com
Heat shock protein 70 (Hsp70) is frequently overexpressed in many different tumor types.
However, Hsp70 has also been shown to be selectively presented on the plasma membrane …