Metabolomics meets systems immunology

J Fu, F Zhu, CJ Xu, Y Li - EMBO reports, 2023 - embopress.org
Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

Ageing with HIV: Challenges and biomarkers

B Rodes, J Cadinanos, A Esteban-Cantos… - …, 2022 - thelancet.com
The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the
prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease …

Metabolic perturbation associated with COVID-19 disease severity and SARS-CoV-2 replication

S Krishnan, H Nordqvist, AT Ambikan, S Gupta… - Molecular & Cellular …, 2021 - ASBMB
Viruses hijack host metabolic pathways for their replicative advantage. In this study, using
patient-derived multiomics data and in vitro infection assays, we aimed to understand the …

Altered plasma metabolites and inflammatory networks in HIV-1 infected patients with different immunological responses after long-term antiretroviral therapy

L Lu, Y Yang, Z Yang, Y Wu, X Liu, X Li… - Frontiers in …, 2023 - frontiersin.org
Background Chronic metabolic changes relevant to human immunodeficiency virus type 1
(HIV-1) infection and in response to antiretroviral therapy (ART) remain undetermined …

Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome

C Depommier, A Everard, C Druart, D Maiter… - Gut …, 2021 - Taylor & Francis
Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted
signature associated with obesity-related metabolic disorders. Using untargeted …

Metabolomics and lipidomics strategies in modern drug discovery and development

G Astarita, RS Kelly, J Lasky-Su - Drug Discovery Today, 2023 - Elsevier
Metabolomics and lipidomics have an increasingly pivotal role in drug discovery and
development. In the context of drug discovery, monitoring changes in the levels or …

Biological aging in people living with HIV on successful antiretroviral therapy: do they age faster?

SS Akusjärvi, U Neogi - Current HIV/AIDS Reports, 2023 - Springer
Abstract Purpose of Review In the absence of a prophylactic/therapeutic vaccine or cure, the
most amazing achievement in the battle against HIV was the discovery of effective, well …

Metabolomics as a tool to investigate HIV/TB co-infection

C Liebenberg, L Luies, AA Williams - Frontiers in molecular …, 2021 - frontiersin.org
The HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) and
tuberculosis (TB) pandemics are perpetuated by a significant global burden of HIV/TB co …

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical …

H Mataramvura, MJ Bunders, K Duri - Frontiers in immunology, 2023 - frontiersin.org
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …

Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

F Mikaeloff, M Gelpi, R Benfeitas, AD Knudsen… - Elife, 2023 - elifesciences.org
Multiomics technologies improve the biological understanding of health status in people
living with HIV on antiretroviral therapy (PWH). Still, a systematic and in-depth …