Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
Hedgehog/GLI signaling pathway: transduction, regulation, and implications for disease
AN Sigafoos, BD Paradise, ME Fernandez-Zapico - Cancers, 2021 - mdpi.com
Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …
development and it is commonly dysregulated in many diseases, including cancer. This …
Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened
S Pietrobono, S Gagliardi, B Stecca - Frontiers in genetics, 2019 - frontiersin.org
The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …
role in controlling cell specification, cell–cell interaction and tissue patterning during …
Signaling cross talk between TGF-β/Smad and other signaling pathways
K Luo - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors
TK Rimkus, RL Carpenter, S Qasem, M Chan, HW Lo - Cancers, 2016 - mdpi.com
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …
Hedgehog signaling and truncated GLI1 in cancer
D Doheny, SG Manore, GL Wong, HW Lo - Cells, 2020 - mdpi.com
The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …
consequence of improper control, aberrant HH signaling results in tumorigenesis and …
Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition
R Derynck, BP Muthusamy, KY Saeteurn - Current opinion in cell biology, 2014 - Elsevier
Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …
GLI1: a therapeutic target for cancer
JT Avery, R Zhang, RJ Boohaker - Frontiers in oncology, 2021 - frontiersin.org
GLI1 is a transcriptional effector at the terminal end of the Hedgehog signaling (Hh) pathway
and is tightly regulated during embryonic development and tissue patterning/differentiation …
and is tightly regulated during embryonic development and tissue patterning/differentiation …