The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …

Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-
2) poses a significant global public health threat. While urgent regulatory measures in …

Simple Summary Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been
extensively studied for the antiviral function and, therefore, its role in the innate and adaptive …

The prognostic value of Toll-like receptor 3 (TLR3) is debated in cancer, differing between
tumor types, methods, and cell types. We recently showed for the first time that TLR3 …

Nucleic acids derived from microorganisms are powerful triggers for innate immune
responses. Proteins called RNA and DNA sensors detect foreign nucleic acids and, in …

Background & Aims Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular
carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of …

Background Toll-like receptor 3 (TLR3) not only plays a crucial role in innate immune and
inflammation but also in anti-cancer immunity. Nevertheless, the clinicopathological …

Introduction: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a
member of the Tumor Necrosis Factor (TNF) superfamily, which stimulates apoptosis in a …