Alkaloids and isoprenoids modification by copper (I)-catalyzed Huisgen 1, 3-dipolar cycloaddition (click chemistry): toward new functions and molecular architectures

K Kacprzak, I Skiera, M Piasecka, Z Paryzek - Chemical reviews, 2016 - ACS Publications
Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

Linear diterpenes from the marine brown alga Bifurcaria bifurcata: a chemical perspective

J Munoz, G Culioli, M Köck - Phytochemistry reviews, 2013 - Springer
This article will give a complete overview of linear diterpenes isolated from the brown alga
Bifurcaria bifurcata. For this purpose all published acyclic diterpenoids are listed and …

Anti-oxidant and anti-melanogenic properties of essential oil from peel of pomelo cv. Guan Xi

W He, X Li, Y Peng, X He, S Pan - Molecules, 2019 - mdpi.com
Here, we investigated the anti-oxidant and anti-melanogenic effects of pomelo peel
essential oil (PPEO) from pomelo cv. Guan Xi. The volatile chemical composition of PPEO …

Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds

MA Prasad, CP Zolnik, J Molina - Future Science OA, 2019 - Taylor & Francis
Aim: The goal of this study was to use phylogenetic evidence to determine plant families with
high representation of antibacterial activity and identify potential sources to focus on for …

Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: Structure–activities relationships of polysubstituted triazoles

D Linares, O Bottzeck, O Pereira… - Bioorganic & medicinal …, 2011 - Elsevier
In order to discover novel probes that may help in the investigation and the control of
bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole …

Antitrypanosomal and antileishmanial activity of prenyl-1, 2, 3-triazoles

EOJ Porta, SN Jäger, I Nocito, GI Lepesheva… - …, 2017 - pubs.rsc.org
A series of prenyl 1, 2, 3-triazoles were prepared from isoprenyl azides and different
alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as …

Regioselective Conversion of Arenes to N‐aryl‐1,2,3‐triazoles Using CH Borylation

R Srinivasan, AG Coyne, C Abell - Chemistry–A European …, 2014 - Wiley Online Library
A one‐pot protocol for the synthesis of N‐aryl 1, 2, 3‐triazoles from arenes by an iridium‐
catalyzed C H borylation/copper catalyzed azidation/click sequence is described. 1 mol …

Sub-lethal activity of small molecules from natural sources and their synthetic derivatives against biofilm forming nosocomial pathogens

F Villa, S Villa, A Gelain… - Current topics in medicinal …, 2013 - ingentaconnect.com
Nowadays, the patient safety is seriously jeopardized by the emergence and spread of
nosocomial pathogens in the form of biofilm that is resistant to traditional and affordable …

Preparation of azidoaryl-and azidoalkyloxazoles for click chemistry

CM Loner, FA Luzzio, DR Demuth - Tetrahedron letters, 2012 - Elsevier
A series of azidoaryl-and azidoalkyl (diphenyl) oxazole scaffolds were warranted for biofilm
inhibition studies. Cyclization of azidoaryl-or azidoalkyl esters of benzoin with ammonium …

Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies

S Andjouh, Y Blache - Bioorganic & Medicinal Chemistry Letters, 2015 - Elsevier
A library of triazole-based analogs of bromotyramine alkaloids such as verongamines,
hemibastadins, pseudoceramine D and clavatidine E was designed in order to identify …