Bisphosphonates (BPs) are highly effective in treating osteoporosis and reducing hip,
vertebral, and other fractures by as much as 50% to 70%. However, since 2006, atypical …

Bone volume, microstructure and its material composition are maintained by bone
remodelling, a cellular activity carried out by bone multicellular units (BMUs). BMUs are …

Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis
and reduce fracture risk in postmenopausal women by up to 50%. However, in the past …

Bone is an architecturally complex system that constantly undergoes structural and
functional optimisation through renewal and repair. The scanning electron microscope …

Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …

Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but
the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we …

Bionic titanium bone tissue engineering implants were constructed by computer-aided
design and fabricated by selected laser melting. Novel interconnected porous structure was …

The prevention of fragility fractures in bone—pathologic fractures resulting from daily activity
and mostly occurring in the elderly population—has been a long-term clinical quest. Recent …

Osteogenesis imperfecta entrains changes at every level in bone tissue, from the
disorganization of the collagen molecules and mineral platelets within and between …

Chronic kidney disease (CKD) is a common disease of aging and increases fracture risk
over advanced age alone. Aging and CKD differently impair bone turnover and …