Lassa fever research priorities: towards effective medical countermeasures by the end of the decade

KA Moore, JT Ostrowsky, AJ Mehr… - The Lancet Infectious …, 2024 - thelancet.com
In 2016, WHO designated Lassa fever a priority disease for epidemic preparedness as part
of the WHO Blueprint for Action to Prevent Epidemics. One aspect of preparedness is to …

Self-amplifying RNA virus vectors for drug delivery

K Lundstrom - Expert Opinion on Drug Delivery, 2025 - Taylor & Francis
Introduction Viral vectors have proven useful for delivering genetic information, such as
drugs and vaccines, for therapeutic and prophylactic interventions. Self-amplifying RNA …

Health and economic impacts of Lassa vaccination campaigns in West Africa

DRM Smith, J Turner, P Fahr, LA Attfield, PR Bessell… - Nature medicine, 2024 - nature.com
Lassa fever is a zoonotic disease identified by the World Health Organization (WHO) as
having pandemic potential. This study estimates the health-economic burden of Lassa fever …

Emerging patterns in rodent-borne zoonotic diseases

F Keesing, RS Ostfeld - Science, 2024 - science.org
Rodents are ubiquitous and typically unwelcome dwellers in human habitats worldwide,
infesting homes, farm fields, and agricultural stores and potentially shedding disease …

[HTML][HTML] Understanding Viral Haemorrhagic Fevers: Virus Diversity, Vector Ecology, and Public Health Strategies

R Hewson - Pathogens, 2024 - mdpi.com
Viral haemorrhagic fevers encompass a diverse group of severe, often life-threatening
illnesses caused by viruses from multiple families, including Arenaviridae, Filoviridae …

Lassa fever in Nigeria: epidemiology and risk perception

AI Al-Mustapha, IM Adesiyan, TG Orum… - Scientific Reports, 2024 - nature.com
Annual outbreaks of Lassa fever have resulted in a public health threat in Nigeria and other
endemic countries in Sub-Saharan Africa. While the Lassa Virus (LASV) is endemic in …

[HTML][HTML] Lassa fever: critical review and prospects for control

ME Besson, M Pépin, PA Metral - Tropical Medicine and Infectious …, 2024 - mdpi.com
Lassa Fever is a deadly viral haemorrhagic disease, causing annually several hundreds of
deaths in West Africa. This zoonotic disease is primarily transmitted to humans by rodents of …

Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa

J Mariën, M Sage, U Bangura, A Lamé… - Emerging Microbes & …, 2024 - Taylor & Francis
ABSTRACT The Natal multimammate mouse (Mastomys natalensis) is the host of Lassa
mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no …

Progress toward the development of Lassa vaccines

H Ly - Expert review of vaccines, 2024 - Taylor & Francis
Mammarenaviruses (also known simply as arenaviruses) originate primarily in rodents and
are divided into Old World (OW) and New World (NW) groups based on their geographical …

Current perspectives on vaccines and therapeutics for Lassa Fever

BM Warner, D Safronetz, DR Stein - Virology Journal, 2024 - Springer
Lassa virus, the cause of deadly Lassa fever, is endemic in West Africa, where thousands of
cases occur on an annual basis. Nigeria continues to report increasingly severe outbreaks …