The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Primary aldosteronism (PA) is a common form of endocrine hypertension previously
believed to account for less than 1% of hypertensive patients. Hypokalemia was considered …

The potent mineralocorticoid aldosterone has a multifaceted role in the pathogenesis of
congestive heart failure. In addition to its contribution to salt and water retention, it also …

Background Experimental and human studies demonstrate that long-term exposure to
elevated aldosterone levels results in cardiac and vascular damage. Methods We …

Heart failure and hypertension have each been linked to an induction of oxidative stress
transduced by neurohormones, such as angiotensin II and catecholamines. Herein, we …

Independent of the severity of coronary artery disease, diabetic patients have an increased
risk of developing heart failure. This clinical entity has been considered to be a distinct …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to
specific mineralocorticoid receptors located in the cytosol of target epithelial cells …

To determine the role of aldosterone in mediating cardiovascular damage, we performed
ablation/replacement experiments with aldosterone in a rat model of cardiac injury …