Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats
KE Poti, DJ Sullivan, AM Dondorp, CJ Woodrow - Trends in parasitology, 2020 - cell.com
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
Variable microtubule architecture in the malaria parasite
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13
protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical …
protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical …
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
A single-cell atlas of Plasmodium falciparum transmission through the mosquito
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell …
uniquely adapted to navigate specific host environments. Here we use single-cell …
In vitro production of infectious Plasmodium falciparum sporozoites
An effective vaccine is needed for the prevention and elimination of malaria. The only
immunogens that have been shown to have a protective efficacy of more than 90% against …
immunogens that have been shown to have a protective efficacy of more than 90% against …
A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum
X Shang, S Shen, J Tang, X He, Y Zhao… - Nucleic acids …, 2021 - academic.oup.com
Gametocytogenesis, the process by which malaria parasites produce sexual forms that can
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
ApiAP2 transcription factors in apicomplexan parasites
MD Jeninga, JE Quinn, M Petter - Pathogens, 2019 - mdpi.com
Apicomplexan parasites are protozoan organisms that are characterised by complex life
cycles and they include medically important species, such as the malaria parasite …
cycles and they include medically important species, such as the malaria parasite …
The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …
encompassing multiple and diverse environmental niches. Invading, replicating, and …
From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium
T Hollin, KG Le Roch - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Over the past decade, we have witnessed significant progresses in understanding gene
regulation in Apicomplexa including the human malaria parasite, Plasmodium falciparum …
regulation in Apicomplexa including the human malaria parasite, Plasmodium falciparum …