Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

GM Pagnotti, M Styner, G Uzer, VS Patel… - Nature Reviews …, 2019 - nature.com
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

The role of bioreactors in tissue engineering

I Martin, D Wendt, M Heberer - TRENDS in Biotechnology, 2004 - cell.com
Ex vivo engineering of living tissues is a rapidly developing area with the potential to impact
significantly on a wide-range of biomedical applications. Major obstacles to the generation …

Inkjet printing of viable mammalian cells

T Xu, J Jin, C Gregory, JJ Hickman, T Boland - Biomaterials, 2005 - Elsevier
The purpose of this study was to explore the use of a commercial thermal printer to deposit
Chinese Hamster Ovary (CHO) and embryonic motoneuron cells into pre-defined patterns …

Proof of principle for transfusion of in vitro–generated red blood cells

MC Giarratana, H Rouard, A Dumont… - Blood, The Journal …, 2011 - ashpublications.org
In vitro RBC production from stem cells could represent an alternative to classic transfusion
products. Until now the clinical feasibility of this concept has not been demonstrated. We …

The mechanical environment of bone marrow: a review

UA Gurkan, O Akkus - Annals of biomedical engineering, 2008 - Springer
Bone marrow is a viscous tissue that resides in the confines of bones and houses the vitally
important pluripotent stem cells. Due to its confinement by bones, the marrow has a unique …

Bioreactor design for tissue engineering

R Pörtner, S Nagel-Heyer, C Goepfert… - Journal of bioscience …, 2005 - Elsevier
Bioreactor systems play an important role in tissue engineering, as they enable reproducible
and controlled changes in specific environmental factors. They can provide technical means …

Stem cell cultivation in bioreactors

CAV Rodrigues, TG Fernandes, MM Diogo… - Biotechnology …, 2011 - Elsevier
Cell-based therapies have generated great interest in the scientific and medical
communities, and stem cells in particular are very appealing for regenerative medicine, drug …

Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system

G Eibes, F dos Santos, PZ Andrade, JS Boura… - Journal of …, 2010 - Elsevier
Bioreactor systems have been developed as alternatives to standard culture flasks due to
their homogeneous nature, easiness of monitoring and increased cell production. Here we …

Generation of human embryonic stem cell‐derived mesoderm and cardiac cells using size‐specified aggregates in an oxygen‐controlled bioreactor

S Niebruegge, CL Bauwens, R Peerani… - Biotechnology and …, 2009 - Wiley Online Library
The ability to generate human pluripotent stem cell‐derived cell types at sufficiently high
numbers and in a reproducible manner is fundamental for clinical and biopharmaceutical …

Covalently immobilized biosignal molecule materials for tissue engineering

Y Ito - Soft matter, 2008 - pubs.rsc.org
Immobilization of biosignal molecules including growth factors and cytokines is important for
developing biologically active materials which can contribute to tissue engineering as a …