▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

Solar radiation induces acute and chronic reactions in human and animal skin. Chronic
repeated exposures are the primary cause of benign and malignant skin tumors, including …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

Summary The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of
cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

The xeroderma pigmentosum group C (XPC) protein complex plays a key role in
recognizing DNA damage throughout the genome for mammalian nucleotide excision repair …

Ultraviolet (UV) light-induced pyrimidine photodimers are repaired by the nucleotide
excision repair pathway. Photolesions have biophysical parameters closely resembling …

Exposure to ultraviolet (UV) radiation is associated with approximately 65% of melanoma
cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell carcinoma …

The DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) is central
to both DNA replication and repair. The ring-shaped homotrimeric PCNA encircles and …

In human cells, efficient global genomic repair of DNA damage induced by ultraviolet
radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 …