Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …

ABSTRACT A group of homologous nucleic acid modification enzymes called Dnmt2,
Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a …

Internal methylation of eukaryotic mRNAs in the form of N6‐methyladenosine (m6A) and 5‐
methylcytidine (m5C) has long been known to exist, but progress in understanding its role …

The Dnmt2 RNA methyltransferase catalyses the methylation of C38 in the anticodon loop of
tRNA-Asp, but the molecular role of this methylation is unknown. Here, we report that mouse …

Protein secretion in eukaryotic cells is a well-studied process, which has been known for
decades and is dealt with by any standard cell biology textbook. However, over the past 20 …

The fission yeast Schizosaccharomyces pombe carries a cytosine 5-methyltransferase
homolog of the Dnmt2 family (termed pombe m ethyl t ransferase 1, Pmt1), but contains no …

The analysis of ribonucleic acids (RNA) by mass spectrometry has been a valuable
analytical approach for more than 25 years. In fact, mass spectrometry has become a …

Methylation is a common post-transcriptional modification of tRNAs, particularly in the
anticodon loop region. The cytosine 38 (C38) in tRNAs, such as tRNAAsp-GUC, tRNAGly …

DNA methylation is an epigenetic event involved in a variety array of processes that may be
the foundation of genetic phenomena and diseases. DNA methyltransferase is a key …

Cells have developed molecular machineries, which can chemically modify DNA and RNA
nucleosides. One particular and chemically simple modification,(cytosine-5) methylation (m …