Blood coagulation, skin-barrier formation, hardening of the fertilization envelope,
extracellular-matrix assembly and other important biological processes are dependent on …

Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Abstract Knowledge of protein structure can be used to predict the phenotypic consequence
of a missense variant. Since structural coverage of the human proteome can be roughly …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Polymerization of actin filaments directed by the actin-related protein (Arp) 2/3 complex
supports many types of cellular movements. However, questions remain regarding the …

A non-redundant set of 1154 protein structures from the Protein Data Bank was examined
with respect to close interactions between CH-donor and π-acceptor groups. A total of …

This treatise is an update to a preceding highlight (CH/π hydrogen bonds in crystals)
published in this journal 5 years ago (M. Nishio, CrystEngComm, 2004, 6, 130–156). After …

Hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor
superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an …

The chemical shift difference (δ [13 C β]− δ [13 C γ]) is a reference-independent indicator of
the Xaa-Pro peptide bond conformation. Based on a statistical analysis of the 13 C chemical …

The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways.
We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in …