Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

F Jiang, Y Han, Y Liu, Y Xue, P Cheng, L Xiao… - Frontiers in …, 2023 - frontiersin.org
Introduction The Bacillus Calmette-Guérin (BCG) vaccine, currently used against
tuberculosis (TB), exhibits inconsistent efficacy, highlighting the need for more potent TB …

[HTML][HTML] In silico design of a promiscuous chimeric multi-epitope vaccine against Mycobacterium tuberculosis

BT Andongma, Y Huang, F Chen, Q Tang… - Computational and …, 2023 - Elsevier
Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each
year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is …

Protective RNA nanovaccines against Mycobacterium avium subspecies hominissuis

BJB Touray, M Hanafy, Y Phanse… - Frontiers in …, 2023 - frontiersin.org
The induction of an effective immune response is critical for the success of mRNA-based
therapeutics. Here, we developed a nanoadjuvant system compromised of Quil-A and …

Immunoinformatic and reverse vaccinology-based designing of potent multi-epitope vaccine against Marburgvirus targeting the glycoprotein

H Yousaf, A Naz, N Zaman, M Hassan, A Obaid… - Heliyon, 2023 - cell.com
Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although
the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks …

Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins

S Shetty, S Dash, A Kumar, S Vishwanath, SG Kini… - Scientific Reports, 2024 - nature.com
Chlamydia trachomatis (CT) remains a significant infectious cause of blindness and sexually
transmitted infections worldwide. The objective and novelty of this study lie in using different …

Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics …

PG Naully, MI Tan, H Nugrahapraja, AA Artarini… - PloS one, 2024 - journals.plos.org
The major problem in cases of chronic hepatitis B (CHB) is the failure of the patient's
immune response to eliminate the covalently closed circular DNA (cccDNA) …

[HTML][HTML] Novel prophylactic and therapeutic multi-epitope vaccine based on Ag85A, Ag85B, ESAT-6, and CFP-10 of Mycobacterium tuberculosis using an …

MF Nugraha, DA Changestu… - … Public Health and …, 2024 - pmc.ncbi.nlm.nih.gov
Objectives Current tuberculosis (TB) control strategies face limitations, such as low antibiotic
treatment compliance and a rise in multidrug resistance. Furthermore, the lack of a safe and …

[HTML][HTML] Multi-epitope-based vaccine models prioritization against Astrovirus MLB1 using immunoinformatics and reverse vaccinology approaches

A Ali, SL Ali, A Alamri, EM Khatrawi… - Journal of Genetic …, 2025 - Elsevier
Abstract Astrovirus MLB1 (HAstV-MLB1) is non-enveloped RNA virus that cause acute
gastroenteritis infection. Despite research progress about infection and pathogenesis of …

Design and development of a multi‐epitope vaccine for the prevention of latent tuberculosis infection

F Jiang, L Wang, J Wang, P Cheng, J Shen… - Medicine …, 2023 - Wiley Online Library
Background Latent tuberculosis infection (LTBI) often progresses to active tuberculosis,
necessitating the development of novel vaccine to prevent LTBI. In this study, we aimed to …