AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX,
acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation …

Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual
screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having …

A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …

To develop new anti-inflammatory agents with improved pharmaceutical profiles, a series of
new phenyl-pyrazoline-coumarin derivatives (4a∼ 4m) were designed and synthesized …

Abstract A series of 1, 3, 4-thiadiazole-5, 6-diphenyl-triazine hybrids 7a-l have been
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

The multitarget-directed strategy offers an effective and promising paradigm to treat the
complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of …

Triazines are heterocyclic compounds with a variety of biological activities that have been
increasingly studied in recent years due to their versatile structure (three isoforms) and the …