Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Cancers develop within complex tissue environments consisting of diverse innate and
adaptive immune cells, along with stromal cells, vascular networks, and many other cellular …

Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune
escape,. Here, to identify factors that modulate the immune sensitivity of cancer cells, we …

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …

Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …

Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer
treatment, ICB benefits for triple-negative breast cancer (TNBC) remain limited. Through …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Although immunotherapy has revolutionized cancer care, patients with pancreatic ductal
adenocarcinoma (PDA) rarely respond to these treatments, a failure that is attributed to poor …