The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …

Cellular senescence has been implicated in tumor suppression, development, and aging
and is accompanied by large-scale chromatin rearrangements, forming senescence …

DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating
gene expression and DNA replication. However, DNA supercoiling at a genomic scale in …

ABSTRACT G-rich genomic regions can form G4 DNA upon transcription or replication. We
have quantified the potential for G4 DNA formation (G4P) of the 16 654 genes in the human …

DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that
duplicate megabase-sized chromosome segments at specific times during S-phase …

Long introns with short exons in vertebrate genes are thought to require spliceosome
assembly across exons (exon definition), rather than introns, thereby requiring transcription …

INTRODUCTION Cancer arises from clonal expansion of a single cell. Yet, most human
cancers are characterized by extensive intratumor heterogeneity and comprise various …

DNA methylation is known to regulate transcription and was recently found to be involved in
exon recognition via cotranscriptional splicing. We recently observed that exon–intron …