As we age, our immune system's ability to effectively respond to pathogens declines, a
phenomenon known as immunosenescence. This age-related deterioration affects both …

Vaccines are among the greatest inventions in medicine, leading to the elimination or
control of numerous diseases, including smallpox, polio, measles, rubella, and, most …

Heterogeneity in vaccine response, particularly in vulnerable populations like the elderly,
represents a significant public health challenge. We conducted an in-depth examination of …

Background Pneumococcal disease, caused by Streptococcus pneumoniae, imposes a
significant global health burden, particularly affecting vulnerable groups such as the elderly …

The biological progression of aging encompasses complex physiological processes. As
individuals grow older, their physiological functions gradually decline, including …

The proportion of adults older than 65 years will jump from 10% to 20% of the total world
population by 2050, according to the World Health Organization. This shift in demographics …

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and is
responsible for acute invasive and non-invasive infections. Fight against pneumococcus is …

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of
researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences …

Background Pneumococcal diseases pose a significant public health concern globally,
particularly among young children and the elderly. Vaccination plays a crucial role in their …

Immune aging is associated with decreased vaccine responses, but biomarkers for vaccine
responsiveness remain unidentified. We analyzed immunotypes describing baseline …