The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III
and IV) is an essential component in the process of energy storage during oxidative …

Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible
for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil …

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

We report here a new mitochondrial regulation occurring only in intact cells. We have
investigated the effects of dimethylbiguanide on isolated rat hepatocytes, permeabilized …

Physical inactivity represents the fourth leading risk factor for mortality, and it has been
linked with a series of chronic disorders, the treatment of which absorbs~ 85% of healthcare …

▪ Abstract Parkinson's disease (PD) is an age-related neurodegenerative disorder that
affects approximately 1 million persons in the United States. It is characterized by resting …

During apoptosis, mitochondrial membrane permeability (MMP) increases and the release
into the cytosol of pro-apoptotic factors (procaspases, caspase activators and caspase …

Using confocal microscopy, onset of the mitochondrial permeability transition (MPT) in
individual mitochondria within living cells can be visualized by the redistribution of the …

The predominant definition of apoptosis considers that the elimination of the apoptosing cell
is by heterolytic degradation following phagocytosis by an assisting scavenger …