Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …

Despite the crucial role of the hypothalamus in the regulation of the human body,
neuroimaging studies of this structure and its nuclei are scarce. Such scarcity partially stems …

Mr M, a patient with semantic dementia—a neurodegenerative disease that is characterized
by the gradual deterioration of semantic memory—was being driven through the countryside …

This review brings together current knowledge from tract tracing studies to update and
reconsider those limbic connections initially highlighted by Papez for their presumed role in …

With the increasing life expectancy in developed countries, the incidence of Alzheimer's
disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

This multicenter study examined 18F-FDG PET measures in the differential diagnosis of
Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies …

One of the main features of Alzheimer's disease (AD) is the severe reduction of the cerebral
metabolic rate for glucose (CMRglc). In vivo imaging using positron emission tomography …