The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Considerable evidences have shown that autophagy has an important role in tumor
chemoresistance. However, it is still unknown whether the lncRNA HULC (highly …

Nicotinamide (NAM) N-methyltransferase (NNMT) was originally identified as the enzyme
responsible for the methylation of NAM, one of the forms of vitamin B3. Methylated NAM is …

Nicotinamide N-methyltransferase (Nnmt) methylates nicotinamide, a form of vitamin B3, to
produce N 1-methylnicotinamide (MNAM). Nnmt has emerged as a metabolic regulator in …

Accumulating evidence suggest that cerebral microvascular disease increases with
advancing age and is associated with lacunar stroke, leukoaraiosis, vascular dementia and …

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be
longevity regulators, and exerts a key role in the prevention of vascular aging. By aging, the …

Background Cerebral ischemia/reperfusion (I/R) is a pathological process that occurs in
ischemic stroke. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) …

Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem
cells (CSCs), which participate in tumor invasion, therapeutic resistance, and tumor relapse …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …