Chemotherapy has made substantial progress in the therapy of systemic cancer, but the
phar-macological efficacy is insufficient in the treatment of brain metastases. Fractionated …

Stereotactic radiosurgery (SRS) was developed decades ago but only began to impact brain
tumor care when it was coupled with high-resolution brain imaging techniques such as …

Ipilimumab, an antibody that enhances T‐cell activation, may augment immunogenicity of
tumor cells that are injured by radiation therapy. We hypothesized that patients with …

Purpose: Patients with central nervous system (CNS) metastases were excluded from
bevacizumab trials following a case of fatal cerebral hemorrhage in a patient with …

Object To evaluate the role of stereotactic radiosurgery (SRS) in the management of brain
metastases from melanoma, the authors assessed clinical outcomes and prognostic factors …

PURPOSE: Stereotactic radiotherapy (SRT) of brain metastases is considered effective
when long-term local control is obtained. However, dose–effect data are scarce. We …

PURPOSE: To assess the relative radiosensitivities of a large collection of melanoma cell
lines and to determine whether pharmacologic inhibition of mutant B-RAF with PLX-4032 …

Simple Summary Brain metastases are one of the most frequent complications for cancer
patients. Stereotactic radiosurgery is considered a cornerstone treatment for patients with …

The powerful rays of the sun represent a conditio sine qua non for life on earth in its present
form and a major driver for human evolution. However, solar radiation exerts both positive …

Object The authors conducted a study to determine whether prognostic factors and the
applicability of prognostic systems vary by primary tumor site in patients treated with …